2021 San Diego Wolves at New York Mongrels

The Lexington Huskies and New York Mongrels of the NAFL played a regular season game on 12 September 2021 in Week 4 that would go on to be the biggest loss in the league's history. The game gained the name 80–3 for its final score, with the Huskies defeating the Mongrels at New York City. Many believed this game proved the Huskies would win the championship, and they did the same year.