2021 San Diego Wolves at New York Mongrels

The San Diego Wolves and New York Mongrels of the NAFL played a regular season game on 12 September 2021 in Week 4 that would go on to be the biggest loss in the league's history. The game gained the name 80–3 for its final score, with the Wolves defeating the Mongrels at New York City. Many believed this game proved the Wolves would win the championship, however they ultimately lost to the Lexington Huskies.